Dichloropane (RTI-111)


Chemical Nomenclature
Common namesDichloropane, RTI-111
Substitutive name(−)-2β-Carbomethoxy-3β-(3,4-dichlorophenyl)tropane
Systematic nameMethyl (2S,3S)-3-(3,4-dichlorophenyl)-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate


Dichloropane is a derivative of 3-phenyltropane. Methylecgonidine as the direct precursor to this compound. It is produced as a hydrochloride salt in its powdered form.

RTI-111 (also known as Dichloropane or O-401) is a synthetic stimulant of the tropane class. It is structurally similar to cocaine, atropine and hyoscine, as it contains a tropane ring.

Its effects include stimulation, thought acceleration, appetite suppression and euphoria. It is structurally related to cocaine and shares many of its effects, although it notably lacks its local anesthetic properties.

In animal studies, dichloropane had a slower onset and longer duration of action compared to cocaine.