O-Desmethyltramadol (O-DSMT) is an opioid analgesic and an active metabolite. In comparison to tramadol, O-DSMT lacks stimulation and feels considerably closer to that of a traditional opiate. It is also stronger in terms of its potency and has a significantly shorter duration.
O-Desmethyltramadol, or 3-(2-((dimethylamino)methyl)-1-hydroxycyclohexyl)phenol, is an atypical synthetic opioid. O-Desmethyltramadol is loosely analogous to codeine, but is not a morphinan opiate.
O-DSMT is considerably more potent as a μ–opioid agonist compared to tramadol. Additionally, unlike tramadol, it is a high-affinity ligand of the δ- and κ-opioid receptors.
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O-desmethyltramadol (O-DSMT) is an opioid analgesic and the main active metabolite of tramadol. (+)-o-dsmt is the most important metabolite of tramadol produced in the liver after tramadol is consumed. Tramadol is demethylated by the liver enzyme cyp2d6 in the same way and so similarly to the variation in effects individuals who have a less active form of cyp2d6 (“poor metabolisers”) will tend to get reduced analgesic effects from tramadol.
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