Ergotamine is an ergopeptine and part of the ergot family of alkaloids; it is structurally and biochemically closely related to ergoline. It possesses structural similarity to several neurotransmitters, and has biological activity as a vasoconstrictor.
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Ergotamine produces vasoconstriction peripherally as well as damages the peripheral epithelium. In high doses, ergotamine is conducive to vascular stasis, thrombosis, and gangrene. It can increase uterine contractivity and occasionally is used therapeutically immediately post-partum to decrease uterine bleeding.
- Molar mass: 581.66 g/mol
- Formula: C33H35N5O5
- Trade name: Cafergot, Ergomar
- Elimination half-life: 2 hours
- Metabolism: Hepatic